CLEMSON, S.C. -- James Conners smile said it all -- Pittsburgh was happy to once again shuffle up the national championship picture.Hey, sorry to do that. But we wanted this one bad, said Conner, who had two touchdowns and ran for 132 yards in the Panthers 43-42 stunner over No. 2 Clemson on Saturday.Conners 20-yard TD run with 5:17 left inched the Panthers into striking range and Chris Blewitt -- after a kiss on the cheek from coach Pat Narduzzi -- struck a perfect, 48-yard field goal with six seconds left for the winning points.Well remember this one forever, Conner said.So, too, will Clemson (9-1, 6-1 Atlantic Coast Conference, No. 3 AP) which saw its run at perfection halted after escaping so many other jams this season. A fourth-down stop a yard shy saved the Tigers 42-36 win over Louisville on Oct. 1. North Carolina States missed field goal at the end of regulation boosted Clemson to a 24-17 overtime win.This time, it was the Panthers (6-4, 3-3) who made the critical plays.When Clemson was driving for a touchdown already up 42-34, linebacker Saleem Brightwell picked off quarterback Deshaun Watson -- his third interception -- and returned it 70 yards to set up a 20-yard TD by Conner that drew Pitt within 42-40.When Clemson attempted to run out the clock, the Panthers defense (despite allowing 630 yards) stuffed Wayne Gallman a yard short on third and fourth downs to take over near midfield with 58 seconds left.We had a chance to put the game away and they stopped us, Clemson coach Dabo Swinney said. We had been making those kinds of plays this year.Nathan Peterman moved Pitt to the Clemson 30 and Blewitt steadily knocked through.It was Pitts highest-ranked win since defeating Backyard Brawl rival, No. 2 West Virginia, 13-9 in 2007 and spoiling the Mountaineers chances at playing for the national title.Our team had a lot of guts tonight, Narduzzi said.And a whole lot of playmakers to topple the defending ACC champs.Peterman had a career-best five TD passes and 308 yards. Conner rushed for 132 yards and a touchdown. He also caught one of Petermans scoring throws.Blewitt, who had a kick blocked at the end of the opening half, was steely eyed and ready. Narduzzi gave his senior a kiss on the cheek and sent him out for the winning kick.As soon as I saw the kick go up, I knew it was going in, Scott Orndoff said. It was jubilation.Clemson had its offense going. Watson threw for an ACC record 580 yards and three touchdowns. Gallman ran for three TDs and Mike Williams had 15 catches for 202 yards and a touchdown.In the end, it was Clemsons first loss to an unranked opponent in five seasons, a span of 46 games.Come Monday, well start over because its a long season, Watson said. Get ready for Wake Forest. Hopefully, we can clinch the ACC (Atlantic) and punch our ticket for the championship game next week.THE TAKEAWAYPittsburgh: The Panthers showed that Narduzzis program is taking hold. Peterman stayed calm in the face of Clemsons strong pass rush and Conner was able to avoid the Tigers middle duo of Carlos Watkins and Dexter Lawrence to keep Pitt moving.Clemson: Many non-Tiger fans will say this team had it coming after escaping with close wins at home against No. 5 Louisville (42-36 on Oct. 1) and North Carolina State (24-17 in overtime on Oct. 15) after the Wolfpack missed the potential game-winning kick to end regulation. Clemsons path is still clear -- win out and hope its one-loss season is better than most others.POLL IMPLICATIONSExpect a rankings fall for Clemson, certainly from the top five. And theres not that much time left to make up for a loss. After Wake Forest, the Tigers face revived rival South Carolina at Death Valley before potentially heading to Orlando, Florida, for the ACC championship game.RECORD DAYWatsons passing yards broke the 21-year-old mark of Wake Forests Rusty LaRue, who passed for 545 yards against North Carolina State on Nov. 18, 1995. Watson said the record doesnt console him after the loss. Id rather go 0-for-30 with no yards and get the W, he said.SAYING GOODBYEThis wasnt the farewell Clemsons offense wanted. Watson, Gallman, Williams and receiver Artavis Scott are all juniors who were honored with Clemsons seniors Saturday after Swinney said they would all be leaving the program for the NFL after this season. Watson acknowledged wild emotions. Still, Im going to keep a smile on my face, he said.UP NEXTPittsburgh closes the year with two games at home, starting with Duke next week.Clemson will try to earn the ACC Atlantic Division title with a win at Wake Forest next Saturday.---More AP college football: www.collegefootball.ap.orgFake Red Sox Jerseys . Nathan MacKinnon, Jamie McGinn and Jan Hejda also scored for the Avalanche, who won despite being outshot 38-23. MacKinnons goal, also on the power play, came with just over a minute remaining. Boston Red Sox Gear . Their 38th instalment is arguably their biggest fight card to date, including three-title fights and a main event which was selected by the fans. The promotion boasts 14-straight years of business and is operated by MFC president Mark Pavelich, who is often overlooked in this country for the foundation hes established for MMA in Canada. https://www.cheapredsox.com/ . There are surprises among the Vezina candidates, but most of the others are standard top-tier performers, even if the two Hart Trophy runners-ups have never been quite as good as they have been through the first half of the season. Stitched Red Sox Jerseys .25 million option on reliever Jose Veras. Boston Red Sox Store .4 million title. Ryan Riess emerged with the title after a session in which he started behind, but used expert skill to gather the chips to his side amid the unpredictability of no-limit Texas Hold em. Riess put his final opponent Jay Farber all-in with an Ace-King.LAFAYETTE, La. -- Frank Bartley IV hit three 3-pointers and finished with 19 points, Justin Miller scored 18 with nine rebounds and four assists and Louisiana-Lafayette cruised to a 101-69 win over Nicholls State on Thursday night.Bartley made 7 of 9 from the field while P.J. Hardy had 12 points and Bryce Washington added 11 points with 10 rebounds. Scott Plaisance and Jerekius Davis scored 10 apiece for Louisiana.Miller scored 12 and the Ragin Cajuns made 20 of 33 (60.6 percent) to take a 48-35 lead into halftime. TThey scored the first nine points and never trailed as Nicholls State (4-4) shot 40 percent, including 1 of 7 from 3-point range, and committed nine of its 22 turnovers in the first half.ddddddddddddJaDante Fryes 3-pointer pulled the Colonels within 10 with 15:49 left but ULL scored 18 of the next 22.DeAndre Harris led Nicholls State with 21 points.Louisiana scored 41 points off turnovers. ' ' '