SAN FRANCISCO (1-4) at BUFFALO (3-2)Sunday, 1 p.m. EDT, FoxOPENING LINE -- Bills by 7 1/2RECORD VS. SPREAD -- 49ers 1-4, Bills 3-2SERIES RECORD -- 49ers lead 6-5LAST MEETING -- 49ers beat Bills 45-3, Oct. 7, 2012LAST WEEK -- Cardinals beat 49ers 33-21; Bills beat Rams, 30-19AP PRO32 RANKING -- 49ers No. 31, Bills No. 1149ERS OFFENSE -- OVERALL (31), RUSH (8), PASS (31).49ERS DEFENSE -- OVERALL (20), RUSH (31), PASS (10).BILLS OFFENSE -- OVERALL (28), RUSH (3), PASS (32).BILLS DEFENSE -- OVERALL (15), RUSH (13), PASS (17).STREAKS, STATS AND NOTES -- Plenty of coaching connections between staffs. Bills offensive coordinator Anthony Lynn spent two seasons in mid-1990s playing running back for 49ers. San Francisco offensive coordinator Curtis Modkins held same position with Bills from 2010-12, while defensive coordinator Jim ONeil was Bills linebackers coach in 2013. ... QB Colin Kaepernick takes over as 49ers starter after Blaine Gabbert benched. Kaepernick lost job after 2-6 start last year, and then had season-ending left shoulder surgery. Kaepernick has made most news this year by not standing for national anthem. ... RB Carlos Hyde tied for NFL lead with six TDs rushing. Hes scored in three consecutive games for first time in career. ... Niners have scored TDs on 12 of 16 drives that have reached opponents 30. ... SF allowed seven sacks and punted five times in first half during loss to Cardinals. Seeking to avoid first five-game skid since opening 2010 season 0-5. ... Bills seeking to win four straight for first time since opening 2008 season 4-0. ... RB LeSean McCoy has combined 330 yards rushing and three TDs (including one receiving) in past three games since Lynn replaced Greg Roman as offensive coordinator. McCoy faces former coach Chip Kelly for second straight year; Buffalo acquired him in trade with Philadelphia in 2014. ... In three games without starting WR Sammy Watkins (left foot), QB Tyrod Taylor is 53 of 87 for 489 yards with three TDs and one interception. ... Buffalo offense has topped 16 first downs once this year. ... LB Lorenzo Alexander has NFL-leading seven sacks and is first Bills player to have sack in each of first five games of season. ... Buffalos 17 sacks in five games are four fewer than defense had all last season. ... Defense has recovered fumble in five straight games, teams best streak since six-game stretch spanning 2007-08 seasons. Fantasy Tip: McCoy facing defense that has allowed 100-yard rusher in each of past four games, including 157 yards and two touchdowns to Cardinals RB David Johnson.---AP NFL website: www.pro32.ap.org and AP NFL Twitter feed: www.twitter.com/AP-NFL Asics Gel Saga Baratas . With their top three point guards and Kobe Bryant all sidelined by injury, the Lakers signed Marshall out of the D-League on Friday before their home game against Minnesota. 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CHARLOTTE, N.C. -- The Carolina Panthers plan to start second-year running back Cameron Artis-Payne on Sunday against Minnesota with Pro Bowler Jonathan Stewart out because of a hamstring injury.Artis-Payne was inactive for the first two games, but the Panthers consider him more of an every-down back than Fozzy Whittaker, who rushed for 100 yards on 16 carries after Stewart was injured last week against San Francisco.For the most part, who we are is not built around one guy, Carolina coach Ron Rivera said Friday. Jonathan does bring a little something different to the game. There is physicality to the way he plays and runs the ball.But Cameron does a nice job. Hes a physical style runner. Hes not quite Jonathan, but youve got a good mix of guys.Artis-Payne got 60 percent of the running back carriees last season when Stewart missed the final three regular-season games with a knee injury.ddddddddddddHe had 33 carries for 152 yards and one touchdown in those games.Fullback-running back Mike Tolbert was second with 17 carries, and Whittaker had seven.Quarterback Cam Newton actually led the team in rushing during those games with 156 yards and three touchdowns on 21 carries.We feel really comfortable with the guys we have, Rivera said.Artis-Payne feels comfortable despite sitting the first two games.My confidence is through the roof, he said earlier in the week. I dont really worry about proving to people. Everybody here knows I can play. So thats not the big issue. ' ' '